Key result
Arterial infusion of N(G)-monomethyl-l-arginine and indomethacin attenuated leg oxygen uptake during the first 2 minutes of intense exercise compared to control (459 vs 566 ml/min at 45s; P<0.05).
Why the study?
Does a marked reduction in oxygen delivery via double blockade slow leg oxygen uptake kinetics during intense exercise in healthy males?
Does a marked reduction in oxygen delivery via double blockade slow leg oxygen uptake kinetics during intense exercise in healthy males?
p-value: p=<0.05
A marked reduction in oxygen delivery limits the rise in oxygen uptake during the initial phase of intense exercise, suggesting that fast-twitch muscle fibers are highly sensitive to reduced oxygen delivery.
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May constrain early intense exercise performance when oxygen delivery is limited; hypothesis-generating for fast-twitch fiber sensitivity, needs clinical validation.
Christensen et al. (2013) studied Healthy (n=7). Arterial infusion of N(G)-monomethyl-l-arginine and indomethacin vs. Control setting was evaluated on Leg oxygen uptake (Vo2) during the first 2 min of exercise (p=<0.05). Arterial infusion of N(G)-monomethyl-l-arginine and indomethacin attenuated leg oxygen uptake during the first 2 minutes of intense exercise compared to control (459 vs 566 ml/min at 45s; P<0.05).
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