Key result
Low-intensity exercise training normalized baroreflex sensitivity (4.04 vs 2.31 b/min/mmHg) and reversed hypothalamic oxidative stress and inflammation in spontaneously hypertensive rats.
Why the study?
Does low-intensity exercise training improve baroreflex sensitivity and reduce oxidative stress and inflammation in the paraventricular nucleus of spontaneously hypertensive rats?
Population
Male 12-week old spontaneously hypertensive rats and Wistar Kyoto rats.
Comparison
Low-intensity treadmill training vs Sedentary SHR and sedentary WKY rats
Design
Preclinical
Follow-up
8 weeks
Authors
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Hypothesis-generating in hypertensive rat models; leaves open translation of exercise effects on baroreflex sensitivity to patients.
Does low-intensity exercise training improve baroreflex sensitivity and reduce oxidative stress and inflammation in the paraventricular nucleus of spontaneously hypertensive rats?
Absolute Event Rate: 4.04% vs 2.31%
p-value: p=<0.05
Low-intensity exercise training promptly restores baroreflex function in spontaneously hypertensive rats by reducing oxidative stress and pro-inflammatory cytokines in the paraventricular nucleus, preceding reductions in heart rate and blood pressure.
Masson et al. (2014) studied Hypertension (n=80). Low-intensity treadmill training vs. Sedentary protocol was evaluated on Baroreflex sensitivity (BrS) at 2 weeks (p=<0.05). Low-intensity exercise training normalized baroreflex sensitivity (4.04 vs 2.31 b/min/mmHg) and reversed hypothalamic oxidative stress and inflammation in spontaneously hypertensive rats.
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