Key result
Paroxetine 20 mg/d decreased intraplatelet serotonin concentrations by 83% (P<.01) and prolonged closure time by 31% (P<.05) in healthy male volunteers.
Why the study?
Does paroxetine 20 mg/d reduce platelet function and serotonin storage in healthy male volunteers?
RCT
double-blind
randomized
Does paroxetine 20 mg/d reduce platelet function and serotonin storage in healthy male volunteers?
Effect estimate: -83%
p-value: p=<.01
Paroxetine significantly reduces intraplatelet serotonin and inhibits platelet plug formation, suggesting potential anti-thrombotic effects.
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Paroxetine may confer antiplatelet effects; extends RCT evidence for SSRI modulation of platelet function in humans.
Nicole Hergovich (2000) conducted an RCT in Healthy. Paroxetine vs. Placebo was evaluated on intraplatelet serotonin concentrations (-83%, p=<.01). Paroxetine 20 mg/d decreased intraplatelet serotonin concentrations by 83% (P<.01) and prolonged closure time by 31% (P<.05) in healthy male volunteers.
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