Why the study?
Do clomipramine and fluoxetine alter peripheral serotonergic parameters in patients with unipolar depression?
Do clomipramine and fluoxetine alter peripheral serotonergic parameters in patients with unipolar depression?
Patients with unipolar depression exhibit altered platelet serotonergic parameters, with inositol triphosphate levels normalizing only in treatment responders after 12 weeks of clomipramine or fluoxetine.
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Altered platelet serotonergic markers support disease-related dysfunction in depression; leaves open their value as response biomarkers to clomipramine or fluoxetine.
Alvarez et al. (1999) studied this question.
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