Key result
Metabolites involved in glycolysis and the citric acid cycle were elevated up to 5.7-fold in patients with dilated cardiomyopathy compared to controls (p = 1.7 × 10−6).
Why the study?
Because energy production pathways play a pivotal role in heart failure, the authors sought to identify key metabolic changes in ischemic and non-ischemic heart failure using a multi-OMICS approach.
Do energy metabolites serve as biomarkers in patients with ischemic and dilated cardiomyopathy compared to controls?
Case-Control (n=281)
Do energy metabolites serve as biomarkers in patients with ischemic and dilated cardiomyopathy compared to controls?
Effect estimate: 5.7-fold increase
p-value: p=1.7 × 10−6
Energy metabolites involved in glycolysis and the citric acid cycle are significantly elevated in dilated cardiomyopathy, suggesting their potential utility as novel biomarkers and therapeutic targets.
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10−6). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets.
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Haas et al. (2021) conducted a case-control in Heart Failure (Ischemic and Dilated Cardiomyopathy) (n=281). Dilated Cardiomyopathy and Ischemic Heart Failure vs. Controls was evaluated on Elevation of metabolites involved in glycolysis and citric acid cycle (5.7-fold increase, p=1.7 × 10−6). Metabolites involved in glycolysis and the citric acid cycle were elevated up to 5.7-fold in patients with dilated cardiomyopathy compared to controls (p = 1.7 × 10−6).
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