Key result
Suprasternal aortic banding followed by adenoviral gene transfer in rats successfully induced left ventricular hypertrophy and heart failure with homogenous gene expression.
Why the study?
Does a novel suprasternal approach for aortic banding enable efficient gene transfer in a rat model of left ventricular hypertrophy and heart failure?
Population
Sprague-Dawley rats
Design
Preclinical
Follow-up
27 weeks
Authors
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Novel suprasternal banding enables homogenous gene transfer in rat HF models without inflammation; leaves open translation beyond rodents.
Does a novel suprasternal approach for aortic banding enable efficient gene transfer in a rat model of left ventricular hypertrophy and heart failure?
A novel suprasternal approach for aortic banding in rats successfully induces left ventricular hypertrophy and heart failure while allowing for efficient, homogenous in vivo gene transfer without the complication of surgical trauma-induced inflammation.
Monte et al. (2002) studied Left ventricular hypertrophy and heart failure. Suprasternal aortic banding and adenoviral gene transfer was evaluated on Induction of concentric hypertrophy, LV dilatation, and global gene expression. Suprasternal aortic banding followed by adenoviral gene transfer in rats successfully induced left ventricular hypertrophy and heart failure with homogenous gene expression.
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