Why the study?
Does medazepam reduce blood pressure fluctuations during psychological stress in patients with essential hypertension?
Does medazepam reduce blood pressure fluctuations during psychological stress in patients with essential hypertension?
Medazepam significantly alleviates the increase in systolic and diastolic blood pressure induced by psychological stress in patients with essential hypertension.
May blunt stress-induced BP rises in essential hypertension; confirms RCT efficacy of medazepam versus placebo.
A double blind controlled study was carried out in 20 patients with essential hypertension to evaluate an effect of medazepam on blood pressures during mirror drawing test performance. Patients were administered orally a tablet of medazepam (5mg) or placebo three times a day for one week. The results were obtained in the following way by the method of analysis of variance for blood pressures.1) Increasing in blood pressure was significantly alleviated after administration of medazepam in both systolic and diastolic, when compared with that of pre-administration. On the other hand, placebo showed little alleviation.2) Some differences were found between the two groups in the pattern of fluctuations in diastolic blood pressures during mirror drawing test performance.
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Ogawa et al. (1974) studied this question.
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