Key result
Moderate-intensity continuous exercise and interval exercise significantly decreased post-exercise betatrophin levels compared to control (52.38 and 109.31 vs 226.65 pg/mL, p=0.000).
Why the study?
Obesity is linked to elevated betatrophin levels and increased risk of metabolic syndrome, but the effects of moderate-intensity interval versus continuous exercise on lowering betatrophin levels and its relation to obesity markers were unclear.
Does moderate-intensity exercise reduce betatrophin levels in young women?
RCT (n=30)
randomly divided
Does moderate-intensity exercise reduce betatrophin levels in young women?
Absolute Event Rate: 52.38% vs 226.65%
p-value: p=0.000
Moderate-intensity continuous exercise is more effective than interval exercise in acutely lowering circulating betatrophin levels in young women.
Acute exercise may lower betatrophin; hypothesis-generating and requires validation before clinical consideration.
OBJECTIVES: Positive energy homeostasis due to overnutrition and a sedentary lifestyle triggers obesity. Obesity has a close relationship with elevated levels of betatrophin and may increase the risk of developing metabolic syndrome. Therefore, lifestyle modification through a nonpharmacological approach based on physical exercise is the right strategy in lowering betatrophin levels. This study aimed to analyze the effect of moderate-intensity interval and continuous exercises on decreased betatrophin levels and the association between betatrophin levels and obesity markers in women. METHODS: A total of 30 women aged 20-24 years old were randomly divided into three groups. Measurement of betatrophin levels using Enzyme-Linked Immunosorbent Assay (ELISA). Data analysis techniques used were one-way ANOVA and parametric linear correlation. RESULTS: The results showed that the average levels of betatrophin pre-exercise were 200.40 ± 11.03 pg/mL at CON, 203.07 ± 42.48 pg/mL at MIE, 196.62 ± 21.29 pg/mL at MCE, and p=0.978. Average levels of betatrophin post-exercise were 226.65 ± 18.96 pg/mL at CON, 109.31 ± 11.23 pg/mL at MIE, 52.38 ± 8.18 pg/mL at MCE, and p=0.000. Pre-exercise betatrophin levels were positively correlated with age, BMI, FM, WHR, FBG, and PBF (p≤0.001). CONCLUSIONS: Our study showed that betatrophin levels are decreased by 10 min post-MIE and post-MCE. However, moderate-intensity continuous exercise is more effective in lowering betatrophin levels than moderate-intensity interval exercise. In addition, pre-exercise betatrophin levels also have a positive correlation with obesity markers.
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Rejeki et al. (2022) conducted an RCT in obesity (n=30). Moderate-intensity continuous exercise (MCE) and interval exercise (MIE) vs. Control was evaluated on Post-exercise betatrophin levels (p=0.000). Moderate-intensity continuous exercise and interval exercise significantly decreased post-exercise betatrophin levels compared to control (52.38 and 109.31 vs 226.65 pg/mL, p=0.000).
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