The Role and Relationship of Betatrophin with Exercise Among Obese Patients in Gym Centers in Mosul City

Q: What are the key findings of this study?

One month of exercise significantly reduced serum betatrophin levels in obese patients from 586.2 pg/ml to 436.3 pg/ml, alongside improvements in insulin resistance and lipid profiles.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Obesity (n=135). Intervention: Exercise vs. Pre-exercise baseline and healthy controls. Primary outcome: Serum betatrophin level (pg/ml) (p=<0.01).

Q: What does this research mean for the field?

Circulating betatrophin levels are elevated in individuals with obesity and decrease following exercise, showing an inverse relationship with exercise duration. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To determine the effect of exercise and its duration on circulating betatrophin levels and examine its relationship with biochemical parameters and oxidative stress markers in obese individuals.

Israa A. Abdullah; Nawal Th. Younis

doi:10.64252/7e4dn153

August 2, 2025International Journal of Environmental SciencesOpen Access

The Role and Relationship of Betatrophin with Exercise Among Obese Patients in Gym Centers in Mosul City

View Full Paper

Ask AI

Bookmark

Share

Key result

One month of exercise linked to ~26% reduction in serum betatrophin in obese patients.

P<0.01
n=135

Why the study?

The study aimed to investigate the effect of exercise on betatrophin levels and its relationship with biochemical parameters related to obesity.

Does one month of exercise training reduce betatrophin levels and improve metabolic and oxidative stress parameters in obese patients?

Key Points

To determine the effect of exercise and its duration on circulating betatrophin levels and examine its relationship with biochemical parameters and oxidative stress markers in obese individuals.
Evaluated serum betatrophin and metabolic parameters in obese individuals attending gym centers in Mosul City compared to healthy controls, assessed before and after one month of exercise.
Stratified betatrophin concentration across exercise training durations (one month, one year, and more than one year), age groups (35-45 and ≥46 years), and BMI categories.
Measured glycemic profiles, lipid parameters (total cholesterol, triglycerides, LDL-C, VLDL-C, HDL-C), renal markers (urea, creatinine), atherogenic index, and oxidant/antioxidant enzymes.
Serum betatrophin was elevated in obese patients pre-exercise at 586.2±112.6pg/ml compared to healthy controls at 253.6±37.2pg/ml, decreasing to 436.3±95.5pg/ml post-exercise compared to 200.8±23.5pg/ml in controls (p≤0.01).
Betatrophin levels decreased with extended exercise duration (pre- to post-exercise: 707.65 to 541 pg/ml at one month, 597.43 to 411.5 pg/ml at one year, and 480.04 to 325.25 pg/ml at more than a year) and were higher in females (611 + 127.6 pg/ml) than males (557.3 + 94.9 pg/ml; p≤0.01).
Post-exercise evaluations showed decreases in random glucose (160.8 + 12.1 to 133.6 + 10.4 mg/dl), total cholesterol (236.5 39.8 to 205.1 + 28.2 mg/dl), LDL-C (154.6 + 38.8 to 121 + 31.4 mg/dl), and atherogenic index (5.6 + 1 to 4.2 + 0.8; p≤0.05), alongside increases in HDL-C (42.4 + 4.6 to 48.9 + 5.3 mg/dl; p≤0.01).

Study Design

Type

Cohort (n=135)

Multicenter

No

Structured PICO

Does one month of exercise training reduce betatrophin levels and improve metabolic and oxidative stress parameters in obese patients?

P

Population

135 adults (75 obese patients and 60 healthy controls) aged 35 and older from gym centers in Mosul, Iraq, evaluated for betatrophin levels before and after one month of exercise.

I

Intervention

Exercise training for one month.

C

Comparator

Pre-exercise baseline levels (within-group) and normal-weight healthy individuals (between-group).

O

Outcome

Betatrophin level (pg/ml) in blood serum.surrogate

Main Result

Absolute Event Rate: 436.3% vs 586.2%

p-value: p=<0.01

One month of exercise significantly reduces betatrophin levels and improves lipid profiles and oxidative stress markers in obese patients.

Implication

Exercise-associated betatrophin reduction in obesity is hypothesis-generating; leaves open causal metabolic benefits pending RCTs.

Abstract

Obesity is characterized by an increase in body fat and adipose tissue and is a cause of metabolic syndrome. therefore, the study contributed to studying the effect of exercise on the hormone betatrophin and its relationship to biochemical parameters related to obesity, the results showed that there was a significant increase in the level of betatrophin, which was (586.2±112.6pg/ml) compared to healthy individuals, which was (253.6±37.2pg/ml)pre- exercise, while its level was (436.3±95.5pg/ml) compared to the control group, which was (200.8±23.5pg/ml)post-exercise.also, a significant increase in the level of betatrophin was observed in females more than males, and its level increased with increasing age and BMI ,While the level of betatrophin decreased with increasing duration of exercise,the results showed that pre-exercise there was a significant increase in insulin resistance, glucose, HbA1c , urea, creatinine, cholesterol, triglycerides, LDL-C, VLDL, atherogenic index, peroxidase enzyme, and a decrease in their levels post exercise. while there was a significant decrease in insulin, HDL-C, ARE enzymes, catalase, uric acid pre-exercise and an increase in their levels post-exercise,the research aimed to study the effect of exercise and its duration on the level of betatrophin and some clinical parameters related to obesity, and to study the relationship of betatrophin to antibiotics and oxidative stress..

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Abdullah et al. (2025) conducted a cohort in Obesity (n=135). Exercise vs. Pre-exercise baseline and healthy controls was evaluated on Serum betatrophin level (pg/ml) (p=<0.01). One month of exercise significantly reduced serum betatrophin levels in obese patients from 586.2 pg/ml to 436.3 pg/ml, alongside improvements in insulin resistance and lipid profiles.

synapsesocial.com/papers/6ac1abb2cc6172083c928b2f https://doi.org/10.64252/7e4dn153

View Full Paper

Ask AI

Bookmark

Share

The Role and Relationship of Betatrophin with Exercise Among Obese Patients in Gym Centers in Mosul City

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

The Role and Relationship of Betatrophin with Exercise Among Obese Patients in Gym Centers in Mosul City

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

Keep reading

More related papers