Key result
Long-term anticoagulation shows no benefit for mortality or recurrent cerebrovascular accidents at 20 months.
RCT
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A trial of long-term anticoagulant therapy in patients with cerebrovascular disease was started in October, 1957, and progress during the first 20 months to June, 1959, was reported by At that stage there was no evidence that anticoagulants were reducing either the mortality or the recurrence rate of cerebrovascular accidents; indeed, the data suggested an adverse effect, particularly in hypertensive patients. The trial was therefore modified by withdrawing those who were hypertensive, and we report here the further progress of the trial in its modified form to its conclusion in October, 1961.
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Hill et al. (1962) conducted an RCT in Cerebrovascular disease. Long-term anticoagulant therapy was evaluated on Mortality or recurrence rate of cerebrovascular accidents. Long-term anticoagulant therapy showed no evidence of reducing mortality or recurrence of cerebrovascular accidents at 20 months, prompting withdrawal of hypertensive patients.
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