Doxorubicin cardiotoxicity can present with unusual features resembling classical endomyocardial fibrosis.
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Doxorubicin cardiotoxicity may mimic endomyocardial fibrosis; this single case extends the known spectrum but remains hypothesis-generating.
We report on a case of adriamycin cardiotoxicity occurring in a five-year-old boy treated for rhabdomyosarcoma. In addition to the usual features of myofibrillary degeneration associated with adriamycin, extreme endocardial fibrosis and mural thrombosis affecting the apical segments of both ventricles but particularly the left ventricle was seen at necropsy. The changes resembled classical endomyocardial fibrosis.
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Fitter et al. (1981) studied this question.
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