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Fatal adriamycin cardiomyopathy was associated with left ventricular endocardial fibroelastosis alongside typical advanced myocardial cardiotoxicity in a 12-year-old boy.
This case report highlights the potential for endocardial fibroelastosis to occur in association with fatal doxorubicin-induced cardiomyopathy.
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Endocardial fibroelastosis may accompany fatal adriamycin cardiomyopathy in children; this single case leaves open prevalence and causality.
We report a case of fatal adriamycin cardiomyopathy in a 12-year-old boy treated for Ewing's sarcoma. At necropsy, in addition to the typical changes of advanced cardiotoxicity in the myocardium there was endocardial fibroelastosis, mainly affecting the left ventricle.
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Conroy et al. (1983) studied this question. Fatal adriamycin cardiomyopathy was associated with left ventricular endocardial fibroelastosis alongside typical advanced myocardial cardiotoxicity in a 12-year-old boy.
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