Key result
The peak radial strain rate during early diastole in the posterior segment was significantly decreased in affected (-1.96 /sec) and carrier (-2.19 /sec) dogs compared to normal dogs (-2.93 /sec).
Why the study?
Does speckle tracking echocardiography detect early left ventricular regional myocardial dysfunction in a canine model of Duchenne muscular dystrophy?
Population
22 Beagles aged 8 months or more, including 6 dogs affected with Canine X-linked muscular dystrophy in…
Comparison
Two-dimensional speckle tracking… vs Normal control dogs without history of…
Design
Preclinical
Authors
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Speckle tracking may detect early diastolic dysfunction in DMD canine models; extends validation but leaves open human translation.
Observational (n=22)
No
Does speckle tracking echocardiography detect early left ventricular regional myocardial dysfunction in a canine model of Duchenne muscular dystrophy?
Absolute Event Rate: -1.96% vs -2.93%
p-value: p=<0.05
Speckle tracking echocardiography can detect early impaired cardiac diastolic function in a canine model of Duchenne muscular dystrophy before the onset of obvious left ventricular dilation or clinical signs.
Takano et al. (2011) conducted an observational in Duchenne muscular dystrophy (n=22). Duchenne muscular dystrophy (affected and carrier status) vs. Normal (control) dogs was evaluated on Peak radial strain rate during early diastole (SrRE) in the posterior segment at the chordae tendineae level (p=<0.05). The peak radial strain rate during early diastole in the posterior segment was significantly decreased in affected (-1.96 /sec) and carrier (-2.19 /sec) dogs compared to normal dogs (-2.93 /sec).
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