Key result
Dogs with congestive heart failure due to MMVD had increased global longitudinal strain and strain rates compared with dogs with no or minimal mitral regurgitation (P<0.04).
Why the study?
Does speckle-tracking echocardiography reveal altered global strain and strain rates in dogs with myxomatous mitral valve disease compared to healthy dogs?
Population
93 privately owned dogs with different severities of myxomatous mitral valve disease (MMVD)
Comparison
Speckle-tracking echocardiography (STE) vs Dogs with no or minimal mitral regurgitation
Design
Preclinical
Authors
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Speckle-tracking may detect augmented LV strain in canine MMVD with CHF; leaves open clinical utility and translation pending prospective validation.
Observational (n=93)
Does speckle-tracking echocardiography reveal altered global strain and strain rates in dogs with myxomatous mitral valve disease compared to healthy dogs?
p-value: p=<0.04
Assessed by speckle-tracking echocardiography, left ventricular function appears augmented in moderate-to-severe myxomatous mitral valve disease but decreases at congestive heart failure stages with greatly enlarged atria.
Zois et al. (2012) conducted an observational in Myxomatous mitral valve disease (MMVD) (n=93). Congestive heart failure due to MMVD vs. No or minimal mitral regurgitation was evaluated on Global radial and longitudinal strain (St), strain rate (SR), and indices of LV dyssynchrony (p=<0.04). Dogs with congestive heart failure due to MMVD had increased global longitudinal strain and strain rates compared with dogs with no or minimal mitral regurgitation (P<0.04).
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