Key result
Children with DMD exhibit worse global LV longitudinal strain vs controls despite normal EF.
Why the study?
Speckle-tracking echocardiography had not been assessed in a prospective controlled study in presymptomatic children with Duchenne muscular dystrophy across all three displacements and both ventricles.
Does speckle-tracking echocardiography detect early left ventricular dysfunction in presymptomatic children with Duchenne muscular dystrophy compared to healthy controls?
Population
108 boys including 36 with DMD and 72 age-matched controls
Comparison
Boys with DMD vs age-matched control subjects
Design
Prospective multicenter controlled cross-sectional 1:2 case-control study
Authors
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May enable earlier LV dysfunction detection in DMD with preserved EF; hypothesis-generating for longitudinal outcome studies.
Cross-Sectional (n=108)
Yes
Does speckle-tracking echocardiography detect early left ventricular dysfunction in presymptomatic children with Duchenne muscular dystrophy compared to healthy controls?
Absolute Event Rate: -16.8% vs -20.6%
p-value: p=<.0001
Speckle-tracking echocardiography detects altered left ventricular strain in children with Duchenne muscular dystrophy despite normal conventional LV ejection fraction, highlighting its potential as an early functional biomarker for cardiomyopathy.
Amédro et al. (2019) conducted a cross-sectional in Duchenne muscular dystrophy (n=108). Duchenne muscular dystrophy vs. Age-matched healthy controls was evaluated on Global left ventricular longitudinal strain (p=<.0001). Children with Duchenne muscular dystrophy exhibited significantly worse global left ventricular longitudinal strain compared to controls (-16.8% vs -20.6%, P<0.0001) despite normal ejection fraction.
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