Key result
A critical appraisal of published data on Scn5a+/- mouse models of Brugada syndrome reveals significant methodological flaws and inconsistencies in action potential duration measurements.
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This letter highlights the need for critical appraisal of experimental data and methodology in mouse models of Brugada syndrome due to significant inconsistencies in published electrophysiological parameters.
Tse et al. (2016) conducted a letter in Brugada syndrome. Scn5a+/- mutation (mouse model) vs. Wild-type was evaluated. A critical appraisal of published data on Scn5a+/- mouse models of Brugada syndrome reveals significant methodological flaws and inconsistencies in action potential duration measurements.
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