Key result
Essential hypertension was associated with a higher transcapillary escape rate of albumin compared to normotensive controls, but this leakage was unrelated to the presence of microalbuminuria.
Why the study?
Is microalbuminuria associated with increased systemic transcapillary albumin leakage in men with essential hypertension?
Cross-Sectional (n=94)
Is microalbuminuria associated with increased systemic transcapillary albumin leakage in men with essential hypertension?
In essential hypertension, systemic transcapillary albumin leakage is increased but dissociated from the amount of albuminuria, challenging the hypothesis that higher albumin excretion reflects greater systemic microvascular damage.
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Questions microalbuminuria as marker of systemic permeability in hypertension; hypothesis-generating, needs prospective validation.
Pedrinelli et al. (1999) conducted a cross-sectional in Essential Hypertension (n=94). Essential hypertension vs. Normotensive controls was evaluated on Transcapillary escape rate of albumin (TER(alb)). Essential hypertension was associated with a higher transcapillary escape rate of albumin compared to normotensive controls, but this leakage was unrelated to the presence of microalbuminuria.
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