Key result
Severe essential hypertension was associated with significantly higher plasma BNP levels compared to healthy controls (median 27.7 vs 12.5 ng/l, p=0.015), which may occasionally lead to a misdiagnosis of heart failure.
Why the study?
Does severe essential hypertension raise BNP levels in patients with normal systolic function?
Cross-Sectional (n=105)
No
Does severe essential hypertension raise BNP levels in patients with normal systolic function?
Answers are grounded in this paper and cite their sources.
Severe essential hypertension, especially with left ventricular hypertrophy, can elevate BNP levels above the diagnostic threshold for heart failure even in patients with normal systolic function.
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Jakubik et al. (2006) conducted a cross-sectional in Essential hypertension (n=105). Severe and moderate essential hypertension vs. Healthy normotensive controls was evaluated on Plasma BNP levels (ng/l) (p=0.015). Severe essential hypertension was associated with significantly higher plasma BNP levels compared to healthy controls (median 27.7 vs 12.5 ng/l, p=0.015), which may occasionally lead to a misdiagnosis of heart failure.
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