Key result
Discharge BNP levels ≥434.5 pg/ml and admission BNP levels ≥1699 pg/ml significantly predicted long-term mortality in patients with acutely decompensated chronic systolic heart failure (HR 3.29 and 2.79, respectively).
Why the study?
Does admission and discharge BNP assessment predict mortality in patients hospitalized for acutely decompensated chronic systolic heart failure?
Cohort (n=130)
No
Does admission and discharge BNP assessment predict mortality in patients hospitalized for acutely decompensated chronic systolic heart failure?
Effect estimate: HR 3.29 (95% CI 1.37-7.90)
p-value: p=0.008
Admission and discharge BNP levels are significant predictors of long-term mortality in patients hospitalized for acutely decompensated chronic systolic heart failure.
BNP thresholds may refine mortality risk stratification at admission and discharge; leaves open whether BNP-guided strategies improve outcomes in decompensated systolic HF.
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Ludka et al. (2013) conducted a cohort in acutely decompensated chronic systolic heart failure (n=130). BNP assessment at admission and discharge vs. BNP below cut-off values was evaluated on Long-term mortality (discharge BNP ≥ 434.5 pg/ml) (HR 3.29, 95% CI 1.37-7.90, p=0.008). Discharge BNP levels ≥434.5 pg/ml and admission BNP levels ≥1699 pg/ml significantly predicted long-term mortality in patients with acutely decompensated chronic systolic heart failure (HR 3.29 and 2.79, respectively).
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