Key result
Polymorphisms in the CD14, CRP, and FGB genes were significantly associated with Kawasaki disease (p<0.05), while the CD14 polymorphism was also associated with coronary artery aneurysms (p<0.05).
Why the study?
Kawasaki disease is a multifactorial systemic vasculitis complicated by coronary artery aneurysms, prompting the search for associated genetic polymorphisms in IL6, VEGFA, CD14, CRP, and FGB.
Are specific gene polymorphisms (IL6, VEGFA, CD14, CRP, FGB) associated with the development of Kawasaki disease and coronary artery aneurysms in children?
Case-Control (n=61)
Are specific gene polymorphisms (IL6, VEGFA, CD14, CRP, FGB) associated with the development of Kawasaki disease and coronary artery aneurysms in children?
p-value: p=<0.05
Polymorphisms in CD14, CRP, and FGB genes may be associated with the development of Kawasaki disease, with CD14 specifically linked to coronary artery aneurysm formation in a Russian pediatric cohort.
May inform future Kawasaki risk stratification; hypothesis-generating and requires validation before clinical use.
Kawasaki disease (KD) is a multifactorial disease with a genetic predisposition, systemic vasculitis complicated by the formation of coronary artery aneurysms (CAA). Its pathogenesis is based on immune inflammation with an increase in the concentration of pro-inflammatory cytokines, the level of C-reactive protein (CRP), and coagulation disorder. Objective of the study: to search for polymorphisms of genes interleukin-6 (IL6), vascular endothelial growth factor A (VEGFA), cluster of differentiation CD14, CRP, fibrinogen beta chain (FGB), associated with the KD development and a predisposition to the CAA formation among patients with KD living in Moscow and the Moscow region. Materials and methods: genotyping for gene polymorphisms IL6 –174G>C (rs1800795), VEGFA –634 C>G (rs2010963), CD14 –159 C>T (rs2569190), CRP 3872 C>T (rs1205), FGB – 455 G>A (rs1800790) by PCR in 31 children 1 month – 10 years old (median age 19 months [9,0; 38,5]) with KD, among them, in 10 patients the disease was complicated by CAA formation according to echocardiography, and 30 children of the control group. Results: statistically significant differences (p<0,05) were revealed in the distribution of genotypes for polymorphisms of the CD14 –159 C>T, CRP 3872 C>T and FGB –455 G>A genes among patients with KD and children of the control group; when comparing the results of KD patients with CAA and the control group, statistically significant differences (p<0,05) were revealed only in the polymorphism CD14 –159 C>T. Conclusion: it can be assumed that these polymorphisms are associated with the development of KD and CAA in these patients.
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Kantemirova et al. (2021) conducted a case-control in Kawasaki disease and coronary artery aneurysms (n=61). Polymorphisms of genes IL6, VEGFA, CD14, CRP, FGB vs. Control group (children without Kawasaki disease) was evaluated on Distribution of genotypes for polymorphisms of the CD14, CRP, and FGB genes (p=<0.05). Polymorphisms in the CD14, CRP, and FGB genes were significantly associated with Kawasaki disease (p<0.05), while the CD14 polymorphism was also associated with coronary artery aneurysms (p<0.05).
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