Key result
Among adult kidney transplant recipients, delayed-onset CMV disease occurred more frequently than early-onset disease (4.0% vs 1.2%) and was associated with increased risk of inpatient death (HR 2.1 for >365 days posttransplant).
Why the study?
What are the risk factors for delayed-onset CMV disease and its association with inpatient death in adult kidney transplant recipients?
Cohort (n=15,848)
Yes
What are the risk factors for delayed-onset CMV disease and its association with inpatient death in adult kidney transplant recipients?
Absolute Event Rate: 4% vs 1.2%
Delayed-onset CMV disease is more common than early-onset disease in kidney transplant recipients and is associated with an increased risk of inpatient death.
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May warrant prolonged CMV monitoring after kidney transplant; leaves open whether targeted prophylaxis reduces mortality.
Santos et al. (2014) conducted a cohort in Kidney transplantation (n=15,848). Delayed-onset period (>100 days posttransplant) vs. Early-onset period was evaluated on CMV disease. Among adult kidney transplant recipients, delayed-onset CMV disease occurred more frequently than early-onset disease (4.0% vs 1.2%) and was associated with increased risk of inpatient death (HR 2.1 for >365 days posttransplant).