Key result
Hospital initiation of MRA therapy was associated with higher rates of adequate potassium and creatinine monitoring compared to primary care (33% vs 17%; OR 2.85, 95% CI 2.34-3.56).
Population
4,036 heart failure patients starting mineralocorticoid receptor antagonist therapy in Stockholm, Sweden…
Design
Cohort
Follow-up
90 days
Authors
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Hospital MRA initiation may enhance monitoring adherence; observational data leave open effects on safety and need for prospective trials.
Cohort (n=4,036)
Yes
Odds Ratio: 2.85 (95% CI 2.34–3.56)
Absolute Event Rate: 33% vs 17%
Despite guideline recommendations, post-initiation monitoring of potassium and creatinine in heart failure patients starting MRAs remains suboptimal, particularly in primary care settings.
Nilsson et al. (2018) conducted a cohort in Heart failure (n=4,036). Hospital initiation of MRA therapy vs. Primary care initiation was evaluated on Adequate potassium and creatinine monitoring in all three recommended intervals (pre-initiation, Days 1-10, and Days 11-90) (OR 2.85, 95% CI 2.34-3.56). Hospital initiation of MRA therapy was associated with higher rates of adequate potassium and creatinine monitoring compared to primary care (33% vs 17%; OR 2.85, 95% CI 2.34-3.56).
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