Key result
Cryo-EM 3D classification of rhinovirus A89 asymmetric units revealed that VP4 and the N-terminal extension of VP1 adopt different conformations at the RNA interface, suggesting local asymmetry.
Design
3D classification from a 2.9 Å cryo-EM density map
Authors
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Structural heterogeneity at rhinovirus RNA interface may affect capsid dynamics; leaves open functional role in assembly.
Dieter Blaas (2020) studied Rhinovirus A89. Cryo-EM 3D-classification was evaluated on Protein-RNA contact site conformations. Cryo-EM 3D classification of rhinovirus A89 asymmetric units revealed that VP4 and the N-terminal extension of VP1 adopt different conformations at the RNA interface, suggesting local asymmetry.
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