The complete nucleotide sequence of human rhinovirus 14 was determined, revealing a 7208-nucleotide genome with significant homology to polioviruses.
The complete nucleotide sequence of human rhinovirus 14 reveals a closer genetic relationship between the rhinovirus and enterovirus genera than previously suspected.
The complete nucleotide sequence of the single-stranded RNA genome of human rhinovirus 14, one of the causative agents of the common cold, has been determined from cDNA cloned in E. coli. The genome is typical of the picornaviridae family, comprising a 5' non-coding region of 624 nucleotides, a long open reading frame of 6537 nucleotides (90.8% of the genome) and a 3' non-coding region of 47 nucleotides. Comparison of the nucleotide sequence and the predicted amino acid sequence with those of the polioviruses reveals a surprising degree of homology which may allow recognition of regions of antigenic importance and prediction of the virus polyprotein cleavage sites. The results presented here imply a closer genetic relationship between the rhinovirus and enterovirus genera than previously suspected.
Stanway et al. (Sun,) conducted a other in Human rhinovirus 14 (Common cold). Nucleotide sequencing was evaluated on Complete nucleotide sequence determination. The complete nucleotide sequence of human rhinovirus 14 was determined, revealing a 7208-nucleotide genome with significant homology to polioviruses.