Crystallization of a common cold virus, human rhinovirus 14: “Isomorphism” with poliovirus crystals
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Population
Human rhinovirus 14 (R14) grown in rhinovirus-sensitive HeLa cells
Comparison
Crystallization and x-ray diffraction analysis vs Type I poliovirus crystals (historical comparison)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Isomorphism suggests shared picornavirus architecture; leaves open whether it informs broad antiviral strategies.
Structured PICO
P
Population
Human rhinovirus 14 (R14) grown in rhinovirus-sensitive HeLa cells
I
Intervention
Crystallization and x-ray diffraction analysis
C
Comparator
Type I poliovirus crystals (historical comparison)
O
Outcome
Crystal structure, unit cell dimensions, space group, and diffraction resolutionsurrogate
The crystallization of human rhinovirus 14 reveals structural isomorphism with poliovirus, suggesting common structural features between enteroviruses and rhinoviruses.
Cite This Study
Erickson et al. (1983) studied this question.
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