Key result
Low-saturated fat dietary counseling was not associated with arterial distensibility, which decreased with age from 11 to 19 years, particularly in boys.
Why the study?
Does low-saturated fat dietary counseling improve arterial distensibility in children and young adults?
RCT (n=472)
Does low-saturated fat dietary counseling improve arterial distensibility in children and young adults?
Vascular distensibility decreases significantly from childhood to early adulthood, particularly in boys, and is related to changes in left ventricular mass.
Answers are grounded in this paper and cite their sources.
Low-saturated fat counseling shows no link to arterial distensibility in youth; leaves open other influences on age-related vascular decline, especially in boys.
UNLABELLED: In adults, arterial distensibility decreases with age and relates to changes in cardiac left ventricular mass. Longitudinal data on changes in arterial distensibility from childhood to adulthood are lacking. Our aim was to study the effect of age and sex, and low-saturated fat dietary counseling on arterial distensibility from childhood to early adulthood. In addition, we assessed the association of arterial distensibility with left ventricular mass. Distensibility of the abdominal aorta and common carotid artery was measured repeatedly at ages 11, 13, 15, 17, and 19 years (n=395-472) in an atherosclerosis prevention trial (Special Turku Coronary Risk Factor Intervention Project [STRIP]). Aortic and carotid distensibility decreased with age (both P<0.0001). In boys, distensibility values were generally lower (P<0.0001) and showed steeper decrease by age (age and sex interaction: both P<0.01). The low-saturated fat dietary counseling given in STRIP was not significantly associated with arterial distensibility. Left ventricular mass increased with age (P<0.0001), and it was greater in boys (P<0.0001). In conclusion, a marked age-related decrease in vascular distensibility was found already at this young age, and this decrease was more pronounced in boys than girls. The longitudinal progression of aortic and carotid distensibility was related with changes in left ventricular mass. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00223600.
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Mikola et al. (2014) conducted an RCT in Atherosclerosis prevention (n=472). Low-saturated fat dietary counseling was evaluated on Distensibility of the abdominal aorta and common carotid artery. Low-saturated fat dietary counseling was not associated with arterial distensibility, which decreased with age from 11 to 19 years, particularly in boys.
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