What question did this study set out to answer?

To evaluate the long-term risk and determinants of unprovoked seizures following central nervous system infections.

September 1, 1988Neurology

The risk of unprovoked seizures after encephalitis and meningitis

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Authors

JAJ. F. AnnegersMayo Clinic WHW. Allen HauserCenter for Pain and the Brain EBEttore BeghiUniversità Cattolica del Sacro Cuore

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Implication

Population-based cohort study finds elevated long-term unprovoked seizure risk in CNS infection survivors, indicating that infection type and early seizures strongly predict future epilepsy.

Key Points

To evaluate the long-term risk and determinants of unprovoked seizures following central nervous system infections.
Followed a population-based cohort of 714 survivors of encephalitis or meningitis diagnosed between 1935 and 1981 for up to 20 years.
Stratified seizure risk by type of central nervous system infection (viral encephalitis, bacterial meningitis, aseptic meningitis) and presence of early acute-phase seizures.
The overall 20-year risk of developing unprovoked seizures was 6.8%, representing an observed-to-expected ratio of 6.9, with the highest incidence occurring within the first 5 years.
The 20-year risk was 22% for viral encephalitis with early seizures versus 10% without early seizures, and 13% for bacterial meningitis with early seizures versus 2.4% without early seizures.
Patients with aseptic meningitis had a 20-year risk of 2.1%, which was not elevated compared to the general population incidence.

Cite This Study

Annegers et al. (1988) studied this question.

synapsesocial.com/papers/6a734076b7c0b64c22c3ff07 https://doi.org/10.1212/wnl.38.9.1407

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Implication

Population-based cohort study finds elevated long-term unprovoked seizure risk in CNS infection survivors, indicating that infection type and early seizures strongly predict future epilepsy.

The risk of unprovoked seizures after encephalitis and meningitis

Discussion

Member takes

Implication

Key Points

Cite This Study

The risk of unprovoked seizures after encephalitis and meningitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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