What question did this study set out to answer?

Assess developmental changes in the transient outward K+ current (Ito) in mouse ventricular myocytes.

Developmental Changes in Transient Outward Current in Mouse Ventricle

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Mouse Ito-APD findings are hypothesis-generating; leaves open translation to human arrhythmia mechanisms or therapies.

Assess developmental changes in the transient outward K+ current (Ito) in mouse ventricular myocytes.
Whole-cell patch-clamp technique used to measure Ito density across different developmental stages.
Microelectrode studies conducted to evaluate action potential duration in neonates and adults.
Ito density increased significantly from 3 +/- 1 pA/pF in day-1 neonates to 19 +/- 4 pA/pF in adults (P < .01).
Inactivation kinetics slowed during development, with distinct inactivation functions between age groups.
Action potential duration decreased progressively with age, with 4-aminopyridine having a greater effect on adults than neonates.

Wang et al. (1997) studied this question.

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