Population
Fetal, neonatal (day-1 and day-3), and adult mouse ventricles and ventricular myocytes
Design
Preclinical
Authors
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Developmental IKr loss may affect neonatal antiarrhythmic responses; extends prior age-dependent K+ current observations in mice.
The expression of delayed rectifier K+ channels (IKr and IKs) is developmentally regulated in the mouse heart, with IKr being dominant in fetal stages and absent in adults.
Wang et al. (1996) studied this question.
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