January 1, 2000AJP Cell Physiology

Age-dependent response of the electrocardiogram to K⁺channel blockers in mice

View Full Paper

Ask AI

Bookmark

Population

Conscious, unsedated neonatal (days 1, 7, 14) and adult male mice (>60 days of age)

Design

Preclinical

Authors

LWLi WangBGI Group (China)SSShauni SwirpUniversity of Calgary HDHenry J. DuffElectrophysiology

Discussion

Member takes

Implication

Age-specific K+ blocker responses in mice caution against pediatric extrapolation; leaves open developmental repolarization mechanisms for human study.

Structured PICO

Population

Conscious, unsedated neonatal (days 1, 7, 14) and adult male mice (>60 days of age)

Intervention

Selective K(+) channel blockers: Dofetilide (0.5 mg/kg) and 4-aminopyridine (4-AP, 2.5 mg/kg)

Outcome

Developmental changes in electrocardiogram (ECG) and response to selective K(+) channel blockerssurrogate

ECG intervals and configuration change during normal postnatal development in mice, with K+ channel blockers affecting the ECG differently depending on age due to shifts in dominant repolarizing currents.

Cite This Study

Wang et al. (2000) studied this question.

synapsesocial.com/papers/6a78dd94c72ca19efaf99c41 https://doi.org/10.1152/ajpcell.2000.278.1.c73

View Full Paper

Ask AI

Bookmark

Implication

Age-specific K+ blocker responses in mice caution against pediatric extrapolation; leaves open developmental repolarization mechanisms for human study.

Age-dependent response of the electrocardiogram to K⁺channel blockers in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Age-dependent response of the electrocardiogram to K⁺channel blockers in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider