Why the study?
Does maintenance of left coronary artery inflow preserve cardiac metabolism in a dog model of ventricular fibrillation?
Does maintenance of left coronary artery inflow preserve cardiac metabolism in a dog model of ventricular fibrillation?
Maintenance of coronary perfusion during ventricular fibrillation preserves myocardial high-energy phosphates and glycogen in a canine model.
Answers are grounded in this paper and cite their sources.
Does not support changes in clinical VF resuscitation; leaves open translation of perfusion effects to human cardiac arrest.
The cardiac metabolism of the fibrillating left ventricle of the dog heart with and without maintenance of left coronary artery inflow was investigated. During ventricular fibrillation without maintenance of coronary flow, myocardial adenosine triphosphate and glycogen fell progressively, and in vitro oxygen consumption of biopsied tissue initially increased, but with adequate coronary perfusion these elements were maintained. With reinstitution of coronary flow after 30 to 40 minutes of fibrillation without flow, resynthesis of high energy phosphate occurred. The coronary artery-coronary sinus oxygen difference and left ventricular oxygen usage both decreased in the perfused fibrillating heart as compared with the values in the beating heart.
No takes yet. Share an insight, caveat, or question.
Paul et al. (1954) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: