July 1, 1985Cardiovascular Research

Metabolic evidence of inadequate coronary blood flow during closed-chest resuscitation in dogs

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Why the study?

Does closed-chest CPR maintain aerobic myocardial metabolism in dogs with ventricular fibrillation?

Structured PICO

Does closed-chest CPR maintain aerobic myocardial metabolism in dogs with ventricular fibrillation?

Population

6 dogs with ventricular fibrillation

Intervention

20 minute period of closed-chest cardiopulmonary resuscitation (CPR)

Comparator

Prearrest/control values (before CPR)

Outcome

Left ventricular adenosine triphosphate (ATP) and lactate concentrationssurrogate

Coronary blood flow during closed-chest CPR is inadequate to meet myocardial oxygen demands during ventricular fibrillation in dogs.

Discussion

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Implication

Closed-chest CPR permits anaerobic myocardial metabolism during VF in dogs; leaves open whether perfusion-optimized techniques can restore aerobic conditions clinically.

Cite This Study

Ditchey et al. (1985) studied this question.

synapsesocial.com/papers/6a963386793119d355d7ae58 https://doi.org/10.1093/cvr/19.7.419

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Implication

Closed-chest CPR permits anaerobic myocardial metabolism during VF in dogs; leaves open whether perfusion-optimized techniques can restore aerobic conditions clinically.

Metabolic evidence of inadequate coronary blood flow during closed-chest resuscitation in dogs

Structured PICO

Discussion

Implication

Cite This Study

Metabolic evidence of inadequate coronary blood flow during closed-chest resuscitation in dogs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider