Key result
Progressive cardiac tamponade caused a continuous decline in coronary artery blood flow from 1.26 to 0.53 ml/min/g (p<0.01) without evidence of lactate production.
Why the study?
Does progressive cardiac tamponade alter coronary artery blood flow and myocardial oxygen requirements in a conscious dog model?
Population
Seven mongrel dogs, chronically instrumented, conscious euvolemic canine model recovered from surgery
Comparison
Progressive cardiac tamponade induced by… vs Baseline (pericardial space drained of fluid)
Design
Preclinical
Follow-up
within 25 minutes
Authors
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Supports reduced coronary flow without ischemia in dogs; leaves open human translation and clinical relevance.
Does progressive cardiac tamponade alter coronary artery blood flow and myocardial oxygen requirements in a conscious dog model?
Absolute Event Rate: 0.53% vs 1.26%
p-value: p=<0.01
In a conscious dog model, progressive cardiac tamponade reduces coronary blood flow and myocardial oxygen consumption without causing myocardial ischemia or lactate production.
Klopfenstein et al. (1987) studied Cardiac tamponade (n=7). Progressive cardiac tamponade induced by intrapericardial saline infusion vs. Baseline (pericardial space drained of fluid) was evaluated on Coronary artery blood flow (ml/min/g) (p=<0.01). Progressive cardiac tamponade caused a continuous decline in coronary artery blood flow from 1.26 to 0.53 ml/min/g (p<0.01) without evidence of lactate production.
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