Key result
In dogs with acute cardiac tamponade, vagotomy resulted in significant residual depressed cardiac performance compared to intact vagus, indicating a myocardial protective effect of the vagus nerve.
Why the study?
How does autonomic blockade and vagal state affect hemodynamic responses during acute cardiac tamponade in a canine model?
Population
27 closed-chest, alpha-chloralose-anesthetized dogs
Comparison
Acute cardiac tamponade induced by infusing… vs Comparisons between different autonomic states
Design
Preclinical
Authors
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Hypothesis-generating for vagal protection in tamponade; leaves open human relevance and any therapeutic implications.
How does autonomic blockade and vagal state affect hemodynamic responses during acute cardiac tamponade in a canine model?
In a canine model of acute cardiac tamponade, a sympathetic neurohumoral response supports cardiac performance while the vagus nerve exerts a myocardial protective effect modulated by vagal afferents.
Frıedman et al. (1977) studied Acute cardiac tamponade (n=27). Vagotomy vs. Vagus intact was evaluated on Hemodynamic parameters including cardiac output and left ventricular systolic pressure. In dogs with acute cardiac tamponade, vagotomy resulted in significant residual depressed cardiac performance compared to intact vagus, indicating a myocardial protective effect of the vagus nerve.
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