Key result
Two pregnant patients with mechanical heart valves treated with low-molecular weight heparin developed valve thrombosis requiring emergency surgery, resulting in fetal loss but maternal recovery.
Case Report (n=2)
LMWH therapy in pregnant patients with mechanical heart valves may fail to prevent valve thrombosis, leading to severe maternal and fetal complications.
LMWH may fail to prevent valve thrombosis in pregnant mechanical valve patients; leaves open optimal regimens for prospective evaluation.
Life-long anticoagulation therapy is mandatory for patients with mechanical heart valves in order to prevent thromboembolic events. However, controversy still exists concerning which anticoagulant therapy protocol is best for pregnant patients with mechanical heart valves. In this article, we present two pregnant cases of mechanical heart valve thrombosis who were followed up with low-molecular weight heparin (LMWH) therapy. The patients, who were switched from anticoagulants to LMWH to prevent fetal side effects during pregnancy, underwent emergency surgery due to mechanical heart valve thrombosis in the 10th w eek a nd s ixth m onth o f pregnancy, respectively. Although fetal and baby loss occurred, the patients recovered in the postoperative period and were discharged uneventfully.
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Mete Hıdıroğlu (2012) conducted a case report in Pregnant patients with mechanical heart valves (n=2). Low-molecular weight heparin (LMWH) was evaluated on Mechanical heart valve thrombosis requiring emergency surgery. Two pregnant patients with mechanical heart valves treated with low-molecular weight heparin developed valve thrombosis requiring emergency surgery, resulting in fetal loss but maternal recovery.
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