Key result
Surgical weight loss increased the amount of each adiponectin oligomer, including the monomer, suggesting an improvement in whole-body energy metabolism.
Why the study?
Does surgical weight loss alter the serum levels of adiponectin oligomers and tissue expression of ADIPORs in obese patients?
Observational (n=69)
Does surgical weight loss alter the serum levels of adiponectin oligomers and tissue expression of ADIPORs in obese patients?
Surgical weight loss increases adiponectin oligomer levels, suggesting their potential utility as indicators of adipose tissue function improvement in obesity.
May aid assessment of metabolic recovery after bariatric surgery; extends observational data on adiponectin oligomers but remains hypothesis-generating.
OBJECTIVE: Adiponectin is an adipocytokine that exerts beneficial effects on obesity and related disorders by two receptors (ADIPORs). Adiponectin is produced as a monomer that circulates in serum as different oligomers. The oligomerization state and the tissue expression of adiponectin and ADIPORs are linked to its biological activities. In this study, the levels of total adiponectin and its oligomers were evaluated in relation to obesity and surgical weight loss. The expression of adiponectin and ADIPORs was analyzed in visceral and subcutaneous adipose tissues of obese patients. DESIGN AND METHODS: In 25 obese patients and 44 age- and sex-matched controls, the serum levels of adiponectin and its oligomers were measured and compared by ELISA, western blotting, and gel filtration. The expression of adiponectin and ADIPORs in both adipose tissues was evaluated by real-time quantitative PCR and western blotting. RESULTS: The amount of each adiponectin oligomer, including the monomer, increases after weight loss. The reduced circulating levels of adiponectin and its oligomers are not associated with the adipose tissue depot-specific expression of adiponectin and ADIPORs. CONCLUSIONS: Our results suggest that in patients, adiposity is associated with the serum concentrations of adiponectin and its oligomers but not with adipose tissue depot-specific expression of adiponectin and ADIPORs. In particular, the increase in adiponectin monomer levels could probably be related to the improvement of the whole-body energy metabolism then being involved in the improvement of adipose tissue function after weight loss. This work indicates the importance of assessing the whole adiponectin oligomeric profile as further potential indicators of adipose tissue functions in obesity.
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Rosa et al. (2013) conducted an observational in Obesity (n=69). Surgical weight loss vs. Pre-weight loss state and healthy controls was evaluated on Serum levels of adiponectin and its oligomers, and expression of adiponectin and ADIPORs. Surgical weight loss increased the amount of each adiponectin oligomer, including the monomer, suggesting an improvement in whole-body energy metabolism.
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