Why the study?
Does intravenous naloxone improve neurological outcomes and reduce mortality in patients presenting within 24 hours of acute ischemic stroke?
Does intravenous naloxone improve neurological outcomes and reduce mortality in patients presenting within 24 hours of acute ischemic stroke?
Early administration of intravenous naloxone in acute ischemic stroke may improve neurological outcomes and reduce 30-day mortality.
Supports early IV naloxone in acute ischemic stroke within 24 h; confirms neurological and mortality benefits in this RCT.
Patients presenting within less than 24 h after the onset of ischemic stroke were randomly assigned to receive naloxone 20 mg i.v. over 6 h (n = 50) or placebo (n = 60). Two patients had naloxone discontinued for possible adverse reactions. The neurological status was assessed using the Mathew scale. In the naloxone-treated group neurological improvement was faster and at the end of the observation period (30 days) the number of patients with better neurological outcome was higher. The number of deaths was lower in the naloxone group (6.25%) than in the placebo group (20%).
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Członkowska et al. (1992) studied this question.
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