Why the study?
Does naloxone improve motor strength in patients with acute stroke?
Does naloxone improve motor strength in patients with acute stroke?
Naloxone does not appear to improve motor deficits in acute stroke and may be associated with worsening symptoms or increased motor tone.
Naloxone may worsen motor tone or strength in acute stroke; hypothesis-generating and requires prospective trials before any consideration.
Naloxone failed to improve motor strength in any of 19 patients with acute stroke, even though 4 patients eventually demonstrated complete recovery. Two patients worsened, and sensory abnormalities increased in two others. Motor tone increased in eight patients. Naloxone amelioration of stroke deficits is therefore not common, and this treatment may not be entirely benign.
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Cutler et al. (1983) studied this question.
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