Why the study?
Does incremental maximal exercise reveal impaired prefrontal cortex hemodynamics in poorly controlled patients with uncomplicated type 1 diabetes compared to healthy controls?
Population
36 subjects total: 18 patients with uncomplicated type 1 diabetes and 18 healthy control subjects matched…
Comparison
Incremental maximal exercise vs Healthy control subjects matched for physical…
Design
Cross-sectional
Authors
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Blunted cerebral hemodynamics during exercise may indicate early endothelial dysfunction in T1D; hypothesis-generating and requires prospective validation.
Does incremental maximal exercise reveal impaired prefrontal cortex hemodynamics in poorly controlled patients with uncomplicated type 1 diabetes compared to healthy controls?
Poorly controlled type 1 diabetes is associated with blunted regional cerebral hemodynamic responses during maximal exercise, suggesting early brain endothelial dysfunction prior to overt microangiopathy.
Tagougui et al. (2015) studied this question.
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