What question did this study set out to answer?

To prospectively evaluate the reproducibility of positive and negative diagnostic results, as well as the hemodynamic response type, in head-up tilt testing for unexplained syncope.

March 1, 1996Clinical CardiologyOpen Access

Reproducibility of head‐up tilt test in patients with syncope

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Population

64 consecutive patients with syncope of unknown cause, mean age 34.6 +/- 22.9 years

Design

Cohort

Follow-up

9.77 +/- 8.21 days (interval between tests)

Authors

ARAurora RuizUniversity of Richmond JSJorge ScaglioneHospital Pedro de Elizalde JGJorge González‐ZuelgarayUniversity of Buenos Aires

Discussion

Member takes

Implication

Modest positive HUT reproducibility cautions against serial testing to assess syncope treatment response; leaves open validation of more reliable endpoints.

Key Points

To prospectively evaluate the reproducibility of positive and negative diagnostic results, as well as the hemodynamic response type, in head-up tilt testing for unexplained syncope.
Prospective cohort evaluation of 64 consecutive patients (mean age 34.6 ± 22.9 years) presenting with syncope of unknown origin.
Each patient underwent two 60-minute, 75-degree head-up tilt tests separated by an average interval of 9.77 ± 8.21 days.
Multivariate analysis was applied to test for correlations between clinical variables, blood pressure, heart rate, and result reproducibility.
Positive tilt-test responses were reproduced in 54.5% of patients during the second test, whereas negative responses demonstrated a higher reproducibility rate of 84.3%.
Among 31 patients with an initial negative test, 5 developed a positive response on the second test; across 18 patients with reproducible positive responses, 12 (66.6%) exhibited the same response modality.
Multivariate analysis demonstrated that no clinical characteristics, baseline arterial blood pressure, or heart rate measurements significantly correlated with test reproducibility.

Structured PICO

Population

64 consecutive patients with syncope of unknown cause, mean age 34.6 +/- 22.9 years

Intervention

Two head-up tilt tests (HUT) (60 min, 75 degrees), separated by an interval of 9.77 +/- 8.21 days

Outcome

Reproducibility of positive and negative results of the head-up tilt test

The low reproducibility of positive head-up tilt test results (54.5%) limits its usefulness as a tool for evaluating treatment efficacy in patients with syncope.

Cite This Study

Ruiz et al. (1996) studied this question.

synapsesocial.com/papers/6a73531a644e61a44f4e5454 https://doi.org/10.1002/clc.4960190315

Topics

Ventricular arrhythmias

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Implication

Modest positive HUT reproducibility cautions against serial testing to assess syncope treatment response; leaves open validation of more reliable endpoints.

Reproducibility of head‐up tilt test in patients with syncope

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Reproducibility of head‐up tilt test in patients with syncope

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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