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January 31, 2014The Journal of PhysiologyOpen Access

CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)

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Editorial

Authors

MPMarc PourrierSWSarah WilliamsDMDonald A. McAfee

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Overview

INa,L inhibition merits testing in HFpEF; leaves open clinical efficacy pending prospective trials.

Key Points

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Cite This Study

Pourrier et al. (2014) studied this question.

synapsesocial.com/papers/6a735db429b0f29a5dc67f32https://doi.org/10.1113/jphysiol.2013.262261
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1New Treatment Options for Late Na Current, Arrhythmias, and Diastolic Dysfunction2012 · 20 citations
  2. 2Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat2013 · 27 citations
  3. 3Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure2010 · 84 citations
  4. 4Improvement in Left Ventricular Systolic and Diastolic Performance During Ranolazine Treatment in Patients With Stable Angina2010 · 52 citations
  5. 5Increased Late Sodium Currents are Related to Transcription of Neuronal Isoforms in a Pressure-Overload Model2009 · 62 citations