The value of shear wave elasticity and shear wave dispersion imaging to evaluate the viscoelasticity of renal parenchyma in children with glomerular diseases

Figures

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  Fig. 1. Study design and participants

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  Fig. 2. A, Measurement of kidney shear wave speed with ARFI elastography on healthy kidney. B, Measurement of kidney shear wave speed with ARFI elastography on glomerular diseases. QuadView four mode can simultaneously display short-wave velocity or short-wave elasticity (velocity map, elasticity map), short-wave arrival time contour (propagation map), gray level and dispersion slope (dispersion map)

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  Fig. 3. A shows the difference in renal shear wave velocity values assessed by SWE technique between children with glomerular disease and the control group; B shows the difference in renal frequency slope assessed by SWD technique between children with glomerular disease and the control group

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  Fig. 4. Renal pathology results of a 4-year-old pediatric with Henoch-Schönlein purpura: by HE staining and special staining, it was found that the mesangial cells and stromal stromal were light-to-moderate focal hyperplasia, and the renal interstitium was scattered in inflammatory cell infiltration, without obvious fibrosis

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  Fig. 5. ROC curve of kidney, AUC = 0.95, the SWV cut-off = 1.51 m/s, and the corresponding sensitivity was 83.7% and specificity was 90.7%; AUC = 0.71, the SWD cut-off = 13.1(m/s)/kHz, corresponding to a sensitivity of 67.4% and a specificity of 69.8%

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  Fig. 6. A, Bland–Altman plot of variability for Shear-Wave Velocity measurements; B, Bland–Altman plot of variability for dispersion slope measurements. Horizontal bolded lines indicate 95% upper and lower limits of agreement and the mean in the middle