Why the study?
Does perindopril/indapamide combination reduce albumin excretion rate and blood pressure compared to enalapril in patients with type 2 diabetes, albuminuria, and hypertension?
Population
481 patients with type 2 diabetes, albuminuria, and hypertension, mean age 59+/-9 years, 77% previously…
Comparison
Perindopril 2 mg / indapamide 0.625 mg… vs Enalapril 10 mg daily, adjusted after week 12…
Design
RCT, randomly assigned, double-blind
Follow-up
12 months
Authors
Loading...
Supports perindopril/indapamide over enalapril monotherapy as initial therapy in diabetic hypertension with albuminuria; extends evidence for fixed-dose ACE inhibitor/diuretic combinations.
Does perindopril/indapamide combination reduce albumin excretion rate and blood pressure compared to enalapril in patients with type 2 diabetes, albuminuria, and hypertension?
First-line treatment with low-dose perindopril/indapamide induces a greater decrease in albuminuria than enalapril in patients with type 2 diabetes and hypertension, partially independent of BP reduction.
Mogensen et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: