Key result
Indapamide SR was noninferior to enalapril in reducing urinary albumin-to-creatinine ratio in elderly diabetics (ratio 0.95; 95% CI 0.68-1.34; P=0.0236 for noninferiority).
Why the study?
Does indapamide SR reduce microalbuminuria and blood pressure non-inferiorly to enalapril in elderly hypertensive patients with type 2 diabetes?
RCT (n=187)
Does indapamide SR reduce microalbuminuria and blood pressure non-inferiorly to enalapril in elderly hypertensive patients with type 2 diabetes?
Effect estimate: Ratio 0.95 (95% CI 0.68-1.34)
Absolute Event Rate: 46% vs 47%
p-value: p=0.0236 for noninferiority
No takes yet. Share an insight, caveat, or question.
May support indapamide SR as alternative in elderly T2D with microalbuminuria; leaves open confirmation in larger trials.
PUIG et al. (2006) conducted an RCT in Hypertension and type 2 diabetes with persistent microalbuminuria (n=187). Indapamide SR vs. Enalapril 10 mg once daily was evaluated on Urinary albumin-to-creatinine ratio reduction (Ratio 0.95, 95% CI 0.68-1.34, p=0.0236 for noninferiority). Indapamide SR was noninferior to enalapril in reducing urinary albumin-to-creatinine ratio in elderly diabetics (ratio 0.95; 95% CI 0.68-1.34; P=0.0236 for noninferiority).
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