Why the study?
Does perindopril or nifedipine prevent the progression of albuminuria and decline in GFR in non-hypertensive patients with Type 2 diabetes and microalbuminuria?
Population
77 non-hypertensive patients with Type 2 diabetes and microalbuminuria
Comparison
Perindopril or sustained release nifedipine… vs Placebo
Design
RCT, randomized, open, blinded end point
Follow-up
median 66 months
Authors
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Supports BP reduction with perindopril or nifedipine to slow nephropathy in normotensive type 2 diabetes; extends renoprotection evidence to this population.
Does perindopril or nifedipine prevent the progression of albuminuria and decline in GFR in non-hypertensive patients with Type 2 diabetes and microalbuminuria?
Long-term blood pressure reduction with perindopril or nifedipine stabilizes albumin excretion rate and attenuates GFR decline in non-hypertensive patients with Type 2 diabetes and microalbuminuria.
Jerums et al. (2004) studied this question.
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