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February 1, 2001QJM

Randomized placebo-controlled trial of perindopril in normotensive, normoalbuminuric patients with type 1 diabetes mellitus

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Why the study?

Does perindopril reduce the increase in urine albumin/creatinine ratio in normotensive, normoalbuminuric patients with type 1 diabetes mellitus?

Population

Normotensive patients with type 1 diabetes mellitus, normal serum creatinine, and no microalbuminuria

Comparison

Perindopril vs Placebo

Design

RCT, Randomized, Double-blind

Follow-up

36 months

Authors

JKJan KvetnyUniversity of Copenhagen

Discussion

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Implication

Supports early perindopril to prevent albuminuria rise in normotensive normoalbuminuric type 1 diabetes; extends ACE-inhibitor nephroprotection beyond hypertension or overt disease.

Structured PICO

Does perindopril reduce the increase in urine albumin/creatinine ratio in normotensive, normoalbuminuric patients with type 1 diabetes mellitus?

P
Population
Normotensive patients with type 1 diabetes mellitus, normal serum creatinine, and no microalbuminuria (normal GFR)
I
Intervention
Perindopril
C
Comparator
Placebo
O
Outcome
Urine albumin/creatinine ratio (ACR)surrogate

Perindopril demonstrates a nephroprotective effect by preventing the increase of albuminuria in normotensive, normoalbuminuric patients with type 1 diabetes, independent of ACE genotype.

Cite This Study

Jan Kvetny (2001) studied this question.

synapsesocial.com/papers/6a8850de2c11edba2ecf1fbahttps://doi.org/10.1093/qjmed/94.2.89
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