Why the study?
Does lisinopril or nifedipine reduce the progression to overt albuminuria in normotensive IDDM patients with microalbuminuria?
Population
92 normotensive IDDM patients with microalbuminuria
Comparison
Lisinopril or slow-release nifedipine vs Placebo
Design
RCT, double-blind, double-dummy
Follow-up
3 years
Authors
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Supports lisinopril or nifedipine initiation in normotensive type 1 diabetes with microalbuminuria; extends renoprotective evidence beyond hypertension.
Does lisinopril or nifedipine reduce the progression to overt albuminuria in normotensive IDDM patients with microalbuminuria?
Both lisinopril and nifedipine effectively delay the progression to macroalbuminuria in normotensive patients with type 1 diabetes and microalbuminuria, with lisinopril showing greater efficacy in slowing nephropathy progression.
Crepaldi et al. (1998) studied this question.
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