Why the study?
There is a considerable lack of experimental uniformity for ischemic heart models and types of ischemia.
This review summarizes experimental models of ischemic heart disease to improve modeling and potentially provide more efficient preventative measures.
May enhance reproducibility of animal ischemic heart models; leaves open clinical translation without prospective validation.
Objective: Heart failure is commonly defined as a heart dysfunction associated with pulmonary alveolar blood flow and consequent inability to ensure adequate blood supply to the tissues or to meet the body’s metabolic demand. Currently, there is a considerable lack of experimental uniformity for ischemic heart models as well as types of ischemia. Therefore, our objective is to summarize frequently applied methods that are designed to evaluate ischemic heart diseases. A systematic search was conducted to review experimental models according to keywords. In general, iatrogenic and transgenic cardiomyopathy models were used in the literature. These models were designed to generate global and regional ischemia.Our review is conducted to evaluate experimental models with the intent of improving the modelling of ischemic heart diseases. Poor modelling can contribute to high mortality and morbidity rates in cardiology. Given the wide range of models available, the future animal models of ischemic heart failure will potentially provide more efficient and reliable preventative measures in the fight against complex cardiovascular diseases.
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Güden et al. (2019) studied this question.
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