The db/db diabetic mouse model demonstrates significantly higher mortality and worse adverse cardiac remodeling following myocardial ischemia-reperfusion injury compared to nondiabetic mice, providing a feasible model for studying post-MI heart failure in diabetes.
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Warrants caution extrapolating mouse ischemia outcomes to diabetic patients; extends db/db model for post-MI heart failure studies.
Greer et al. (2005) studied this question.
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