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December 21, 2016Journal of Cardiovascular Pharmacology and Therapeutics

Strategies to Optimize Dual Antiplatelet Therapy After Coronary Artery Stenting in Acute Coronary Syndrome

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Why the study?

Do strategies to optimize DAPT (potent agents, DOACs, duration) improve the benefit-risk ratio in patients with ACS undergoing percutaneous coronary intervention?

Population

Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention

Design

Review

Authors

BPBridget ParavattilHEHazem Elewa

Discussion

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Member takes

Overview

Review of DAPT optimization strategies in ACS; leaves open personalized approaches pending prospective trials.

Structured PICO

Do strategies to optimize DAPT (potent agents, DOACs, duration) improve the benefit-risk ratio in patients with ACS undergoing percutaneous coronary intervention?

P
Population
Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention
I
Intervention
Strategies to optimize dual antiplatelet therapy (DAPT), including use of potent antiplatelet agents (prasugrel or ticagrelor), addition of direct oral anticoagulants (DOACs), and optimizing DAPT duration
O
Outcome
Recurrent thrombotic events and bleeding episodes

Individualizing DAPT duration and agent selection using risk stratification tools is crucial for balancing ischemic and bleeding risks in ACS patients post-PCI.

Cite This Study

Paravattil et al. (2016) studied this question.

synapsesocial.com/papers/6a736b49f9fb99ee2c566506https://doi.org/10.1177/1074248416683048
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